The following software is required to run OneBook:
| Type | Requirement | Known to Work |
| Operating System | Linux, Mac OSX, Windows 95 and above | Slackware 8.1, RedHat 7.2 |
| Java Runtime | Sun JRE 1.3 or later | Sun JRE 1.3.1 and 1.4 |
| Web Application Server | Tomcat 4.0 or later | Tomcat 4.0 and 4.1 |
| Database Manager | MySQL 3.23 or later | MySQL 3.23 |
| Database Driver | MM.MySQL 2.0.7 or higher | MM.MySQL 2.0.7 |
Since OneBook is written in Java, JSP, and SQL, it may be run on a variety of hardware platforms. The following are general recommendations:
| Type | Recommendation | Known to Work |
| Processor | 600MHz Intel Pentium III or equivalent | 800MHz Dual Pentium III |
| Main Memory | 256MB | 256MB |
| Network Connection | T1 (1.544Mbps) | T1 |
| Database Manager | MySQL 3.23 or later | MySQL 3.23 |